Barnard D L, Huffman J H, Morris J L, Wood S G, Hughes B G, Sidwell R W
Utah State University, Logan.
Antiviral Res. 1992 Jan;17(1):63-77. doi: 10.1016/0166-3542(92)90091-i.
A number of anthraquinones, anthrones and anthraquinone derivatives were evaluated for antiviral activity against human cytomegalovirus (HCMV) as well as for cytotoxicity. Of those compounds evaluated, quinalizarin, emodin, rhein, hypericin, protohypericin, alizarin, emodin bianthrone and emodin anthrone showed antiviral activity against a normal laboratory HCMV strain, AD-169. When tested against a ganciclovir-resistant strain of HCMV, the EC50 values for quinalizarin, rhein and alizarin were superior to the values obtained for the AD-169 strain of HCMV. These results suggest that these compounds will be useful as prototypes for synthesizing a class of anti-HCMV drugs that are effective against ganciclovir-sensitive and -resistant strains of HCMV.
对多种蒽醌、蒽酮和蒽醌衍生物进行了抗人巨细胞病毒（HCMV）活性及细胞毒性评估。在所评估的这些化合物中，醌茜、大黄素、大黄酸、金丝桃素、原金丝桃素、茜素、大黄素双蒽酮和大黄素蒽酮对实验室常用的HCMV毒株AD-169显示出抗病毒活性。当针对耐更昔洛韦的HCMV毒株进行测试时，醌茜、大黄酸和茜素的EC50值优于针对HCMV的AD-169毒株所获得的值。这些结果表明，这些化合物将作为合成一类对HCMV的更昔洛韦敏感和耐药毒株均有效的抗HCMV药物的原型。
