Shao Qingqing, Liu Tong, Wang Wenjia, Liu Tianli, Jin Ximing, Chen Zhuo
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Pharmacol. 2022 May 4;13:902626. doi: 10.3389/fphar.2022.902626. eCollection 2022.
Emodin is an anthraquinone derivative that is widely present in natural plants and has a wide spectrum of pharmacological effects, such as antibacterial, anti-inflammatory, anti-fibrotic and anticancer and so on. Through reviewing studies on antiviral effect of emodin in the past decades, we found that emodin exhibits ability of inhibiting the infection and replication of more than 10 viruses and , including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), coxsackievirus B (CVB), hepatitis B virus (HBV), influenza A virus (IAV), SARS-CoV, viral haemorrhagic septicaemia rhabdovirus (VHSV), enterovirus 71 (EV71), dengue virus serotype 2 (DENV-2) and Zika virus (ZIKV). Therefore, this review aims to summarize the antiviral effect of emodin, in order to provide reference and hopes to support the further investigations.
大黄素是一种蒽醌衍生物，广泛存在于天然植物中，具有广泛的药理作用，如抗菌、抗炎、抗纤维化和抗癌等。通过回顾过去几十年关于大黄素抗病毒作用的研究，我们发现大黄素具有抑制10多种病毒感染和复制的能力，这些病毒包括1型单纯疱疹病毒（HSV-1）和2型单纯疱疹病毒（HSV-2）、人巨细胞病毒（HCMV）、EB病毒（EBV）、柯萨奇B组病毒（CVB）、乙型肝炎病毒（HBV）、甲型流感病毒（IAV）、严重急性呼吸综合征冠状病毒（SARS-CoV）、病毒性出血性败血症弹状病毒（VHSV）、肠道病毒71型（EV71）、2型登革热病毒（DENV-2）和寨卡病毒（ZIKV）。因此，本综述旨在总结大黄素的抗病毒作用，以便提供参考，并希望为进一步的研究提供支持。
