MANDEL B, RACKER E
J Exp Med. 1953 Nov;98(5):417-26. doi: 10.1084/jem.98.5.417.
A mucopolysaccharide inhibitor of Theiler's GDVII virus has been purified from intestinal tissue of adult mice. The purified material has been shown to consist chiefly of carbohydrate. Following acid hydrolysis of the inhibitor, several amino adds were found to be present. The carbohydrate components shown to be present thus far are galactose, hexosamine, N-acetylhexosamine, methylpentose, hexurornic acid; an indication has been obtained that sedoheptulose is also present. The available evidence strongly suggests that this mucopolysaccharide, and not some other substance present in minute amounts, is the inhibitor of the GDVII virus.
已从成年小鼠的肠道组织中纯化出一种针对泰勒氏GDVII病毒的粘多糖抑制剂。纯化后的物质主要由碳水化合物组成。对该抑制剂进行酸水解后,发现存在几种氨基酸。目前已证明存在的碳水化合物成分有半乳糖、己糖胺、N - 乙酰己糖胺、甲基戊糖、己糖醛酸;有迹象表明景天庚酮糖也存在。现有证据有力地表明,这种粘多糖而非其他微量存在的物质是GDVII病毒的抑制剂。