MANDEL B, RACKER E
J Exp Med. 1953 Nov;98(5):399-415. doi: 10.1084/jem.98.5.399.
A mucopolysaccharide has been obtained from intestinal tissue of adult mice which inhibits both infectivity and hemagglutination of Theiler's GDVII strain of encephalomyelitis virus of mice. The inhibitor is inactive against the FA and TO strains of Theiler's virus and against the Lansing strain of poliomyelitis virus. In the adult mouse, large amounts of the inhibitor are found only in the small intestine. The small intestine of infant mice, however, contains a considerably smaller amount of inhibitor. Inhibition, both in vivo and in vitro, appears to be the result of an interaction between virus and inhibitor. The intestines of man, monkey, rabbit, rat, cotton rat, hamster, sheep, cow, and pig contain relatively little inhibitor whereas guinea pig intestine contains as much as adult mouse intestine. An enzyme was found in the feces of mice, and several other animals, which is capable of destroying the inhibitory activity of the mucopolysaccharide with the liberation of reducing sugars.
从成年小鼠的肠道组织中获得了一种粘多糖，它能抑制小鼠泰勒氏GDVII株脑脊髓炎病毒的感染性和血细胞凝集作用。该抑制剂对泰勒氏病毒的FA和TO株以及脊髓灰质炎病毒的兰辛株均无活性。在成年小鼠中，大量的抑制剂仅存在于小肠中。然而，幼鼠的小肠中抑制剂的含量要少得多。体内和体外的抑制作用似乎是病毒与抑制剂相互作用的结果。人、猴、兔、大鼠、棉鼠、仓鼠、绵羊、牛和猪的肠道中抑制剂含量相对较少，而豚鼠肠道中的抑制剂含量与成年小鼠肠道中的一样多。在小鼠和其他几种动物的粪便中发现了一种酶，它能够破坏粘多糖的抑制活性并释放还原糖。
