Clark R F, Vance M V
Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona.
Ann Emerg Med. 1992 Mar;21(3):318-21. doi: 10.1016/s0196-0644(05)80897-2.
Diphenhydramine poisoning is characterized most often by anticholinergic effects. Cardiotoxicity and circulatory collapse have rarely been reported after massive ingestions of diphenhydramine and other H1-receptor-blocking agents, although these substances have local anesthetic properties and have been studied as antiarrhythmics. We report the case of a patient who developed a wide-complex tachycardia as a complication of acute diphenhydramine poisoning that responded to IV sodium bicarbonate.
苯海拉明中毒最常表现为抗胆碱能效应。尽管苯海拉明及其他H1受体阻滞剂具有局部麻醉特性且已作为抗心律失常药物进行研究，但大量摄入后很少有心脏毒性和循环衰竭的报道。我们报告了1例急性苯海拉明中毒并发症为宽QRS波心动过速的患者，该患者对静脉注射碳酸氢钠有反应。
