Frank Marshall A, Lund Jeremy, Langley David M, Annis Mitchell, Peredy Tamas R
Emergency Medicine, Florida State University College of Medicine, Sarasota, USA.
Toxicology, Sarasota Memorial Hospital, Sarasota, USA.
Cureus. 2024 Oct 2;16(10):e70719. doi: 10.7759/cureus.70719. eCollection 2024 Oct.
Diphenhydramine (DPH), a readily available first-generation H1 receptor antihistamine, can have severe consequences when taken in excessive amounts and can lead to grave outcomes such as seizures, dysrhythmias, coma, and death. Recognizing the early signs and symptoms of DPH toxicity is crucial. Fortunately, fatal adult cases of DPH overdose are rare. This report describes a near-fatal overdose of a young adult female who experienced recurrent seizures, respiratory failure, and cardiac arrest with the return of spontaneous circulation (ROSC) in the prehospital setting and complete functional recovery. This case underscores the urgency of addressing DPH toxicity and the utility of reversal agents, such as sodium bicarbonate, in sodium channel blockade.
苯海拉明（DPH）是一种容易获得的第一代H1受体抗组胺药，过量服用会产生严重后果，并可能导致癫痫发作、心律失常、昏迷和死亡等严重后果。识别DPH中毒的早期体征和症状至关重要。幸运的是，成人苯海拉明过量致死的病例很少见。本报告描述了一名年轻成年女性的近乎致命的过量服药情况，她在院前环境中出现反复癫痫发作、呼吸衰竭和心脏骤停并恢复自主循环（ROSC），最终实现完全功能康复。该病例强调了应对DPH毒性的紧迫性以及碳酸氢钠等逆转剂在钠通道阻滞中的作用。
