Thomas M J
Department of Biochemistry, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
Free Radic Biol Med. 1992;12(1):89-91. doi: 10.1016/0891-5849(92)90061-k.
The human polymorphonuclear leukocyte generates O2-. and H2O2 when it is treated with uric acid. A transition metal catalyzed reaction between O2-. and H2O2 can give the hydroxyl radical and myeloperoxidase forms hypochlorous acid from H2O2 and chloride. Therefore, the uric acid-induced secretion of oxidants may be responsible for a large part of the inflammation associated with gout.
当人类多形核白细胞用尿酸处理时会产生超氧阴离子（O2-.）和过氧化氢（H2O2）。超氧阴离子和过氧化氢之间的过渡金属催化反应可产生羟基自由基，而髓过氧化物酶可将过氧化氢和氯离子转化为次氯酸。因此，尿酸诱导的氧化剂分泌可能是痛风相关炎症的很大一部分原因。
