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单纯疱疹病毒基因UL41的病毒体诱导宿主关闭产物的鉴定与特性分析

Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41.

作者信息

Smibert C A, Johnson D C, Smiley J R

机构信息

Molecular Virology and Immunology Program, McMaster University, Hamilton, Ontario, Canada.

出版信息

J Gen Virol. 1992 Feb;73 ( Pt 2):467-70. doi: 10.1099/0022-1317-73-2-467.

DOI:10.1099/0022-1317-73-2-467
PMID:1311370
Abstract

The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.

摘要

单纯疱疹病毒UL41基因的病毒体诱导宿主关闭产物是宿主翻译关闭和细胞mRNA降解所必需的。我们使用兔抗肽抗血清来鉴定感染细胞中一种58K UL41相关磷蛋白。我们还提供证据表明，这种蛋白是病毒颗粒的一个组成部分，这与其在病毒体诱导的关闭中的作用一致。

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