Roy A K
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7836.
Proc Soc Exp Biol Med. 1992 Mar;199(3):265-72. doi: 10.3181/00379727-199-43356a.
The target cell sensitivity of steroid hormones is determined by the concerted action of specific hormone receptors and steroid-inactivating enzymes. In recent years, a considerable amount of knowledge has been obtained on hormone receptor concentration-based target cell sensitivity. However, an equal understanding of the role of specific steroid-inactivating enzymes in hormone action is absent. This review highlights the importance of specific steroid-inactivating enzymes in the control of target cell sensitivity of mineralocorticoids, glucocorticoids, androgens, and estrogens. Two classes of enzymes that are actively involved in this process are hydroxysteroid dehydrogenases and hydroxysteroid sulfotransferases. Some of the target cells in which the critical roles of these enzymes have been extensively characterized are those of the kidney, endometrium, and liver. cDNA for many of these enzymes have already been cloned, and rapid progress in the elucidation of this component of steroid hormone action is anticipated.
类固醇激素的靶细胞敏感性由特定激素受体和类固醇失活酶的协同作用决定。近年来，已获得了大量关于基于激素受体浓度的靶细胞敏感性的知识。然而，对于特定类固醇失活酶在激素作用中的作用却缺乏同样的了解。本综述强调了特定类固醇失活酶在控制盐皮质激素、糖皮质激素、雄激素和雌激素的靶细胞敏感性方面的重要性。积极参与这一过程的两类酶是羟基类固醇脱氢酶和羟基类固醇磺基转移酶。这些酶的关键作用已得到广泛表征的一些靶细胞是肾脏、子宫内膜和肝脏的靶细胞。许多这些酶的cDNA已经被克隆，预计在阐明类固醇激素作用的这一组成部分方面将取得快速进展。
