Ayers M W, Besser T E
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040.
Am J Vet Res. 1992 Jan;53(1):83-6.
The effects of alkalinizing agents, administered prior to feeding colostrum, on blood-gas and acid-base values and on absorption of IgG1 were determined in 40 newborn Holstein calves. Two treatments, sodium bicarbonate (3 mEq/kg of body weight, IV) and doxapram HCl (2 mg/kg, IV), were evaluated, using a randomized complete-block experimental design. These treatments resulted in significant (P less than 0.01) alteration of blood-gas and acid-base values, generally in the direction of normal values for adult cattle. Significant least squares mean effects were detected for sodium bicarbonate treatment on blood pH (+ 0.04 units, P less than 0.01), PCO2 (+ 4.1 mm of Hg, P less than 0.01), and HCO3 concentration (+ 4.4 mEq/L, P less than 0.01). Significant least squares mean effects were detected for doxapram HCl treatment on blood pH (+ 0.06 pH units, P less than 0.01) and PCO2 (-5.2 mm of Hg, P less than 0.01). Absorption of colostral IgG1 was not affected by the treatments given or by the altered blood-gas and/or acid-base status.
在40头新生荷斯坦犊牛中，测定了在初乳饲喂前给予碱化剂对血气和酸碱值以及IgG1吸收的影响。采用随机完全区组试验设计，评估了两种处理方法，即碳酸氢钠（3 mEq/kg体重，静脉注射）和盐酸多沙普仑（2 mg/kg，静脉注射）。这些处理导致血气和酸碱值发生显著（P < 0.01）变化，总体上朝着成年牛的正常值方向变化。检测到碳酸氢钠处理对血液pH（+0.04单位，P < 0.01）、PCO2（+4.1 mmHg，P < 0.01）和HCO3浓度（+4.4 mEq/L，P < 0.01）有显著的最小二乘均值效应。检测到盐酸多沙普仑处理对血液pH（+0.06 pH单位，P < 0.01）和PCO2（-5.2 mmHg，P < 0.01）有显著的最小二乘均值效应。初乳IgG1的吸收不受所给予的处理或改变的血气和/或酸碱状态的影响。
