自体细胞诱导的淋巴细胞转化。IV. 自体或同种异体非T淋巴细胞诱导的人T淋巴细胞增殖。
Lymphocyte transformation induced by autologous cells. IV. Human T-lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes.
作者信息
Kuntz M M, Innes J B, Weksler M E
出版信息
J Exp Med. 1976 May 1;143(5):1042-54. doi: 10.1084/jem.143.5.1042.
Abstract
An autologous mixed lymphocyte reaction was demonstrated between T and non-T lymphocytes. Sheep erythrocyte rosetting was used to separate human lymphocytes into T and non-T lymphoid preparations. Non-T lymphocytes stimulated the proliferation of autologous T lymphocytes. The cell in this preparation that was most stimulatory had the characteristics of a K lymphocyte. The allogeneic mixed lymphocyte reaction was also shown to reflect the proliferation of T lymphocytes stimulated by allogeneic non-T lymphocytes. Proliferation of T lymphocytes in the allogeneic mixed lymphocyte culture probably reflects a response to both foreign histocompatibility determinants and determinants present on non-T lymphocytes. It is suggested that the proliferative response of T lymphocytes to autologous non-T lymphocytes may be a step in the process by which T lymphocytes regulate immunity.
摘要
在T淋巴细胞和非T淋巴细胞之间证实了自体混合淋巴细胞反应。采用绵羊红细胞玫瑰花结形成试验将人淋巴细胞分离成T淋巴细胞制剂和非T淋巴细胞制剂。非T淋巴细胞刺激自体T淋巴细胞的增殖。该制剂中最具刺激作用的细胞具有K淋巴细胞的特征。同种异体混合淋巴细胞反应也显示反映了由同种异体非T淋巴细胞刺激的T淋巴细胞的增殖。同种异体混合淋巴细胞培养中T淋巴细胞的增殖可能反映了对异体组织相容性决定簇和非T淋巴细胞上存在的决定簇的反应。有人提出，T淋巴细胞对自体非T淋巴细胞的增殖反应可能是T淋巴细胞调节免疫过程中的一个步骤。
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