Miyasaka N, Sauvezie B, Raff H, Stobo J, Talal N
Rheumatol Int. 1983;3(1):13-7. doi: 10.1007/BF00541226.
T-cell macrophage subset interactions were studied in relation to the decreased autologous mixed lymphocyte reaction (AMLR) in 15 patients with Sjögren's syndrome (SS). Monoclonal antibodies against a macrophage (M theta) subset (Mac-120) stimulatory in the AMLR and against nonpolymorphic determinants of Ia antigen were used to identify adherent M theta. Four patients with decreased AMLR had a reduced percentage of Mac-120+ cells, suggesting that a defect in stimulatory M theta may account for their decreased AMLR. No correlation was found between the magnitude of the AMLR and the percentage of Ia+ M theta. Another six patients with diminished AMLR had a normal to high percentage of Mac-120+ M theta. However, this group of SS patients showed a decreased response to Concanavalin A, suggesting that they may have a defect in the responding T cells. Patients with normal AMLR had normal percentages of Mac-120+ M theta and showed normal responses to T-cell mitogens and alloantigens. These results suggest that a defective AMLR may have multiple causes. SS patients are heterogeneous in this regard and can be sorted into three groups using the AMLR and monoclonal antibodies.
针对15例干燥综合征（SS）患者自体混合淋巴细胞反应（AMLR）降低的情况，研究了T细胞与巨噬细胞亚群之间的相互作用。使用针对AMLR中具有刺激作用的巨噬细胞（Mθ）亚群（Mac-120）以及Ia抗原非多态性决定簇的单克隆抗体来识别黏附性Mθ。4例AMLR降低的患者中，Mac-120+细胞的百分比降低，提示具有刺激作用的Mθ缺陷可能是其AMLR降低的原因。未发现AMLR的强度与Ia+ Mθ的百分比之间存在相关性。另外6例AMLR降低的患者中，Mac-120+ Mθ的百分比正常至高。然而，这组SS患者对刀豆蛋白A的反应降低，提示他们可能在反应性T细胞方面存在缺陷。AMLR正常的患者中，Mac-120+ Mθ的百分比正常，并且对T细胞有丝分裂原和同种异体抗原表现出正常反应。这些结果表明，AMLR缺陷可能有多种原因。在这方面，SS患者具有异质性，使用AMLR和单克隆抗体可将其分为三组。
