Ishiguro A, Nakahata T, Amano Y, Koike K, Komiyama A, Shimbo T
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto.
Rinsho Ketsueki. 1992 Jan;33(1):87-92.
The cause of aplastic anemia associated with hepatitis (AAH) is as yet still unknown. There is a supposed relation to the immune mechanisms, however few reports have shown the effects of monocytes on the pathogenesis in the patients with AAH. We have reported a case of a 12-year-old boy with AAH related to cytomegaloviruses, and studied the hemopoietic progenitors. He showed pancytopenia and hypoplasia of the bone marrow on admission to our hospital. The culture studies showed that mononuclear cells (MNC) of the bone marrow produced few hemopoietic colonies in all cell lineages. However, the depletion of adherent cells from the MNC increased numbers of erythroid, neutrophil-macrophage and megakaryocyte colonies. Furthermore, the addition of adherent cells of the peripheral blood suppressed the colony formation in the aforementioned cell lineages by marrow MNC from which adherent cells, phagocytic cells and T-cells were abrogated. The results way suggest that monocytes play some soles in the pathogenesis of aplasia through inhibitor of hemopoiesis.
与肝炎相关的再生障碍性贫血（AAH）的病因至今仍不清楚。推测其与免疫机制有关，然而，很少有报告显示单核细胞对AAH患者发病机制的影响。我们报告了一例12岁患与巨细胞病毒相关的AAH的男孩病例，并对造血祖细胞进行了研究。他入院时表现为全血细胞减少和骨髓发育不全。培养研究表明，骨髓单个核细胞（MNC）在所有细胞谱系中产生的造血集落很少。然而，从MNC中去除贴壁细胞可增加红系、中性粒细胞-巨噬细胞和巨核细胞集落的数量。此外，添加外周血贴壁细胞可抑制上述细胞谱系中骨髓MNC的集落形成，而这些骨髓MNC中的贴壁细胞、吞噬细胞和T细胞已被去除。结果可能提示单核细胞通过造血抑制因子在发育不全的发病机制中起一定作用。
