Lilleng R, Hagmar B M, Farrants G
Department of Pathology, Norwegian Radium Hospital, Oslo, Norway.
Acta Cytol. 1992 Jan-Feb;36(1):48-54.
This paper presents the cytologic features of fine needle aspiration biopsy specimens from three cases of ductal carcinoma in situ characterized by small and uniform tumor cells growing in a predominantly cribriform pattern without comedo necrosis (low-grade cribriform ductal carcinoma in situ). On cytology, most of the tumor cells were clustered in three-dimensional ductal structures. Occasionally in the clusters the tumor cells were seen bordering central lumina, quite similar to the architecture in histology. A few single tumor cells and no myoepithelium were seen. The background was clear or slightly hemorrhagic, without necrosis. The tumor cells were uniform and had a cylindroid shape, with round or oval nuclei. Morphometrically the mean largest nuclear diameter was 1.5-1.6 times that of a red blood cell. The chromatin was finely granular, with a minute nucleolus and slight condensation along the nuclear membrane. In cut sections all three tumors showed strong immunoreactivity for neuron-specific enolase. Unless the cribriform growth pattern is recognized in the smear, the cytologic diagnosis of this entity is difficult.
本文介绍了3例原位导管癌细针穿刺活检标本的细胞学特征，其特点为肿瘤细胞小且形态一致，主要呈筛状生长模式，无粉刺样坏死（低级别筛状原位导管癌）。在细胞学上，大多数肿瘤细胞聚集成三维导管结构。在这些细胞团中偶尔可见肿瘤细胞围绕中央管腔排列，与组织学结构非常相似。可见少数单个肿瘤细胞，未见肌上皮细胞。背景清晰或稍有出血，无坏死。肿瘤细胞形态一致，呈柱状，核圆形或椭圆形。形态学测量显示，平均最大核直径是红细胞的1.5 - 1.6倍。染色质呈细颗粒状，有微小核仁，核膜周围有轻微凝聚。在切片中，所有3例肿瘤对神经元特异性烯醇化酶均表现出强免疫反应性。除非在涂片上识别出筛状生长模式，否则该实体的细胞学诊断较为困难。
