Lilleng R, Hagmar B
Department of Pathology, Norwegian Radium Hospital, Montebello, Oslo, Norway.
Acta Cytol. 1992 May-Jun;36(3):345-52.
Smears from 10 intraductal carcinomas of the comedo type without microinfiltration were compared with smears from 10 similar tumors with suspected or proven microinfiltration and smears from 10 invasive comedo carcinomas. Microinvasive tumors could not be separated from purely intraductal cases unless tumor cell infiltration in mammary fat was seen in the smear. The tumor cells in most of the intraductal cases were shed in cohesive groups and clusters, lying in necrotic cellular debris and with few or no scattered, single, dissociated tumor cells. Smears from invasive comedo carcinomas invariably showed tumor cell clusters and scattered, single, dissociated tumor cells, often with atypia in excess of what was seen in the intraductal cases. Also, in most cases the invasive tumors did not show a background of necrotic cellular debris.
将10例无微浸润的粉刺型导管内癌涂片与10例疑似或已证实有微浸润的类似肿瘤涂片以及10例浸润性粉刺癌涂片进行比较。除非在涂片中看到肿瘤细胞浸润乳腺脂肪，否则微浸润性肿瘤无法与单纯导管内病例区分开来。大多数导管内病例的肿瘤细胞以粘连的细胞团和簇状脱落，位于坏死的细胞碎片中，很少或没有散在的单个解离肿瘤细胞。浸润性粉刺癌涂片总是显示肿瘤细胞团以及散在的单个解离肿瘤细胞，其异型性通常超过导管内病例所见。此外，在大多数情况下，浸润性肿瘤没有坏死细胞碎片背景。
