Bradac G B, Soffietti R, Riva A, Stura G, Sales S, Schiffer D
Department of Neuroradiology, University of Turin, Italy.
Neuroradiology. 1992;34(1):73-6. doi: 10.1007/BF00588438.
Study of intra-arterial BCNU in 12 patients with recurrent glioblastoma multiforme and 5 patients with recurrent anaplastic astrocytoma already treated by surgery and radiotherapy indicates that the risk of BCNU toxicity can be reduced by the use of relatively low doses (160-180 mg/m2) of BCNU, the use of dextrose as solvent, selective injections of BCNU, and fast "bolus" injections of drug. No certain toxic effects of BCNU were observed in the 17 patients treated this way. Anaplastic astrocytomas, particularly in young patients, seem to respond relatively well to this treatment.
对12例多形性胶质母细胞瘤复发患者和5例间变性星形细胞瘤复发患者进行动脉内卡氮芥治疗的研究表明，这些患者此前均已接受过手术和放疗。研究表明，通过使用相对低剂量（160 - 180 mg/m²）的卡氮芥、使用葡萄糖作为溶剂、选择性注射卡氮芥以及快速“推注”药物，可以降低卡氮芥毒性风险。以这种方式治疗的17例患者未观察到卡氮芥的特定毒性作用。间变性星形细胞瘤，尤其是年轻患者，似乎对这种治疗反应相对较好。
