Roosen N, Lins E, Kiwit J C, Schirmer M, Bock W J
Neurosurgical Clinic, Hospital of the University of Düsseldorf, West Germany.
Acta Radiol Suppl. 1986;369:220-2.
In November 1985, we started a study of intra-arterial (i-a) chemotherapy with ACNU for the treatment of glioblastomas of the central nervous system: 19 patients with histologically proved glioblastoma and recurrent, progressive or newly diagnosed disease were entered. Five patients were treated three times. We observed reduction of mass effect, of neovascularization, and of contrast enhancement. As to the time of survival, or follow-up is too short to allow definite conclusions. The quality of life in those patients who received several courses of chemotherapy, did not deteriorate as evidenced by a constant Karnofsky performance rating score. Systemic complications of i-a chemotherapy were negligible. However, some severe side-effects were seen: cerebral ischemia in two cases, and amaurosis in one. Direct ACNU related neurotoxicity was not seen to the present. According to these preliminary results, we feel encouraged to treat further patients with i-a chemotherapy, particularly in view of the disappointing results of several other treatment modalities in the management of glioblastomas of the brain.
1985年11月，我们开始了一项用阿糖胞苷进行动脉内化疗治疗中枢神经系统胶质母细胞瘤的研究：19例经组织学证实为胶质母细胞瘤且疾病复发、进展或新诊断的患者入组。5例患者接受了3次治疗。我们观察到肿块效应、新生血管形成及对比增强均有所减轻。至于生存时间，随访时间太短，无法得出明确结论。接受几个疗程化疗的患者生活质量并未恶化，卡诺夫斯基功能状态评分保持稳定即为明证。动脉内化疗的全身并发症可忽略不计。然而，出现了一些严重副作用：2例脑缺血，1例黑矇。目前尚未发现与阿糖胞苷直接相关的神经毒性。根据这些初步结果，我们受到鼓舞，继续用动脉内化疗治疗更多患者，特别是鉴于其他几种治疗方式在治疗脑胶质母细胞瘤方面的结果令人失望。
