Westermann K H, Funk K, Pawlowski L
Pharmacol Biochem Behav. 1976 Jan;4(1):1-6. doi: 10.1016/0091-3057(76)90166-0.
Application of harmine (10 mg/kg IP) 30 min before apomorphine decreased the motoric effects of the latter. Following harmine an increase in 5-HT and a decrease in 5-HIAA in different brain regions have been found. Injection of 5,6-DHT into nucleus medianus raphe 7 days before the experiment caused a significant increase of the apomorphine effect. Harmine pretreatment reduced this escessive motility as well as additional lesion of the substantia nigra with 6-OH-DA. Lesion induced by 6-OH-DA alone was without significant effect on the hypermotility following apomorphine. Application of PCPA 3 days before testing elicited an increase of apomorphine-induced hypermotolity which could be abolished by preceding harmine application. The experiments demonstrate the inhibitory effect of the central serotoninergic system on the apomorphine syndrome as well as the serotoninergic-dopaminergic interaction in hypermotility.
在阿扑吗啡给药前30分钟腹腔注射 harmine（10毫克/千克）可降低后者的运动效应。在给予 harmine 后，发现不同脑区的5-羟色胺增加而5-羟吲哚乙酸减少。在实验前7天将5,6-二羟基色胺注射到中缝正中核，可导致阿扑吗啡效应显著增加。Harmine 预处理可减轻这种过度运动以及用6-羟基多巴胺对黑质造成的额外损伤。单独由6-羟基多巴胺诱导的损伤对阿扑吗啡后的运动亢进无显著影响。在测试前3天应用对氯苯丙氨酸可引起阿扑吗啡诱导的运动亢进增加，而预先应用 harmine 可消除这种增加。实验证明了中枢5-羟色胺能系统对阿扑吗啡综合征的抑制作用以及5-羟色胺能-多巴胺能在运动亢进中的相互作用。
