Takashi K, Kuga T
Jpn J Pharmacol. 1981 Oct;31(5):677-88. doi: 10.1254/jjp.31.677.
The role of brain monoamine systems in the jumping behavior induced by the combination of harmine and apomorphine was studied by using a MT pick-up to assess jumping behavior in rats. The jumping induced by the combination of harmine 10 mg/kg and apomorphine 2 mg/kg was enhanced by pretreatment with p-chlorophenylalanine, methysergide and by treatment with clonidine, while, it was reduced by pretreatment with 5-hydroxytryptophan, haloperidol, perphenazine, atropine and pilocarpine. The combination of harmaline or harmane and apomorphine also induced jumping with the aid of p-chlorophenylalanine. The combination of benserazide, L-DOPA and harmine induced jumping similar to that induced by harmine and apomorphine. Despite pretreatment with p-chlorophenylalanine the combination of apomorphine and benzylhydrazine, iproniazid, tranylcypromine or pargyline failed to induce jumping. These results suggest that this jumping behavior is induced not by the monoamine oxidase inhibitory effect of harmine but probably by the specific central action of harmine and on condition that the dopaminergic system is activated. The activation of this system appears to be essential, the noradrenergic system plays a facilitatory role, the serotonergic system an inhibitory role and the cholinergic system probably a specific role.
通过使用MT传感器评估大鼠的跳跃行为，研究了脑单胺系统在 harmine 和阿扑吗啡联合诱导的跳跃行为中的作用。用对氯苯丙氨酸、甲基麦角新碱预处理以及用可乐定处理可增强10mg/kg harmine 与2mg/kg阿扑吗啡联合诱导的跳跃，而用5-羟色氨酸、氟哌啶醇、奋乃静、阿托品和毛果芸香碱预处理则可降低该跳跃。harmaline 或 harmane 与阿扑吗啡的联合在对氯苯丙氨酸的辅助下也可诱导跳跃。苄丝肼、左旋多巴和 harmine 的联合诱导的跳跃与 harmine 和阿扑吗啡诱导的相似。尽管用对氯苯丙氨酸预处理，阿扑吗啡与苄肼、异烟肼、反苯环丙胺或帕吉林的联合仍未能诱导跳跃。这些结果表明，这种跳跃行为不是由 harmine 的单胺氧化酶抑制作用诱导的，而是可能由 harmine 的特定中枢作用以及多巴胺能系统被激活的条件下诱导的。该系统的激活似乎是必不可少的，去甲肾上腺素能系统起促进作用，血清素能系统起抑制作用，胆碱能系统可能起特定作用。
