Kraus D H, Sterman B M, Levine H L, Wood B G, Tucker H M, Lavertu P
Department of Otolaryngology and Communicative Disorders, Cleveland Clinic Foundation, OH 44195-5034.
Arch Otolaryngol Head Neck Surg. 1992 Apr;118(4):367-72. doi: 10.1001/archotol.1992.01880040025005.
Nineteen patients with primary ethmoid sinus malignancies were treated at the Cleveland (Ohio) Clinic Foundation between 1976 and 1989. Pathologic diagnoses included adenocarcinoma (eight), sarcoma (four), squamous cell carcinoma (three), mucoepidermoid carcinoma (two), adenoid cystic carcinoma (one), and undifferentiated carcinoma (one). All patients underwent surgical resection: 13 had craniofacial resection, four had craniofacial resection/orbital exenteration, one had radical ethmoidectomy/maxillectomy/orbital exenteration, and one had transantral ethmoidectomy. Twelve patients had combined treatment with radiation therapy. Ten patients were alive with no evidence of disease. A trend toward improved prognosis is associated with negative surgical margins. Preservation of the globe was not associated with local recurrence at this site. A poor prognosis was noted with involvement of the dura, brain, nasopharynx, or sphenoid sinus.
1976年至1989年间，俄亥俄州克利夫兰诊所基金会收治了19例原发性筛窦恶性肿瘤患者。病理诊断包括腺癌（8例）、肉瘤（4例）、鳞状细胞癌（3例）、黏液表皮样癌（2例）、腺样囊性癌（1例）和未分化癌（1例）。所有患者均接受了手术切除：13例行颅面切除术，4例行颅面切除术/眶内容摘除术，1例行根治性筛窦切除术/上颌骨切除术/眶内容摘除术，1例行经鼻窦筛窦切除术。12例患者接受了放疗联合治疗。10例患者存活，无疾病证据。手术切缘阴性与预后改善趋势相关。保留眼球与该部位局部复发无关。硬脑膜、脑、鼻咽或蝶窦受累时预后较差。
