Kraus D H, Roberts J K, Medendorp S V, Levine H L, Wood B G, Tucker H M, Lavertu P
Department of Otolaryngology and Communicative Disorders, Cleveland Clinic Foundation, OH 44195-5034.
Ann Otol Rhinol Laryngol. 1990 Jan;99(1):5-11. doi: 10.1177/000348949009900102.
Nonsquamous cell malignancies represent half of paranasal sinus cancers. Since 1975, 103 patients have been treated at The Cleveland Clinic Foundation for sinus malignancies. Forty-nine patients had nonsquamous cell malignancies: 12 (25%) sarcoma, 10 (20%) adenoid cystic carcinoma, 9 (18%) adenocarcinoma, 9 (18%) lymphoma, and 9 (18%) miscellaneous tumors. Ten patients presented with T1 or T2 disease at the primary site, 16 with T3, and 23 with T4. Ten patients had primary ethmoid malignancies; the remainder of the tumors originated in the maxillary sinus. Five patients had evidence of regional or distant metastases at presentation. Twelve patients were free of disease after initial management. Three patients with recurrent disease were salvaged with additional therapy. Two patients died of complications in the immediate postoperative period. Patients with less extensive primary lesions have an improved prognosis. Survival was similar for the different histologic diagnoses.
非鳞状细胞恶性肿瘤占鼻窦癌的一半。自1975年以来，克利夫兰诊所基金会已治疗了103例鼻窦恶性肿瘤患者。49例患者患有非鳞状细胞恶性肿瘤：12例（25%）为肉瘤，10例（20%）为腺样囊性癌，9例（18%）为腺癌，9例（18%）为淋巴瘤，9例（18%）为其他肿瘤。10例患者原发部位为T1或T2期疾病，16例为T3期，23例为T4期。10例患者患有原发性筛窦恶性肿瘤；其余肿瘤起源于上颌窦。5例患者初诊时有区域或远处转移证据。12例患者在初始治疗后无疾病。3例复发患者通过额外治疗得以挽救。2例患者在术后即刻死于并发症。原发病变范围较小的患者预后较好。不同组织学诊断的患者生存率相似。
