二乙基二硫代氨基甲酸盐对释放一氧化氮的血管舒张剂活性的影响。

Effect of diethyldithiocarbamate on the activity of nitric oxide-releasing vasodilators.

作者信息

Vedernikov Y P, Mordvintcev P I, Malenkova I V, Vanin A F

机构信息

Cardiology Research Center, U.S.S.R. Academy of Medical Sciences, Moscow.

出版信息

Eur J Pharmacol. 1992 Feb 25;212(1):125-8. doi: 10.1016/0014-2999(92)90085-i.

DOI:10.1016/0014-2999(92)90085-i

PMID:1313370

Abstract

The effect of diethyldithiocarbamate (DETC, 10(-3) M) on the vasorelaxant activity of acetylcholine, nitric oxide (NO), nitrite, glyceryl trinitrate or dinitrosyl iron cysteine complexes was studied in isolated rat aortic rings contracted with norepinephrine. Pretreatment of these segments with DETC attenuated the vasorelaxation induced by vasodilators and prevented the subsequent restoration of vessel tone, whereas DETC added after the vasodilators induced a rapid restoration of tone. The inhibitory effect of DETC was due to the trapping of NO by a complex of DETC with Fe2+ formed in the tissue.

摘要

在去甲肾上腺素收缩的离体大鼠主动脉环中，研究了二乙基二硫代氨基甲酸盐（DETC，10⁻³ M）对乙酰胆碱、一氧化氮（NO）、亚硝酸盐、甘油三硝酸酯或二亚硝基铁半胱氨酸复合物血管舒张活性的影响。用DETC预处理这些节段可减弱血管舒张剂诱导的血管舒张，并阻止随后血管张力的恢复，而在血管舒张剂作用后添加DETC则可迅速恢复血管张力。DETC的抑制作用是由于组织中形成的DETC与Fe²⁺的复合物捕获了NO。