Vedernikov Y P, Mordvintcev P I, Malenkova I V, Vanin A F
Cardiology Research Center, USSR Academy of Medical Sciences, Moscow.
Eur J Pharmacol. 1992 Feb 18;211(3):313-7. doi: 10.1016/0014-2999(92)90386-i.
Dinitrosyl iron complexes with cysteine (DNIC) induced a concentration-dependent relaxation of pre-contracted (norepinephrine, 10(-7) M) de-endothelialized ring segments of rat aorta. The vasodilator response was more similar to acetylcholine (ACh)-induced relaxation in intact aortic rings than to nitric oxide (NO)-induced relaxation. The time course of tone recovery after maximal concentrations (10(-5) M) of DNIC was similar to the time course of tone recovery after endothelium-dependent relaxation induced by ACh, whereas the restoration of tone after NO was much faster. Vessel tone was restored by oxyhemoglobin (10(-5) M) in all cases. The results suggest that DNIC with cysteine may function as endothelium-derived relaxing factor in the vessels.
二亚硝基铁与半胱氨酸的复合物（DNIC）可引起预先收缩（去甲肾上腺素，10⁻⁷ M）的大鼠主动脉去内皮环段浓度依赖性舒张。这种血管舒张反应与完整主动脉环中乙酰胆碱（ACh）诱导的舒张比与一氧化氮（NO）诱导的舒张更相似。最大浓度（10⁻⁵ M）的DNIC作用后张力恢复的时间进程与ACh诱导的内皮依赖性舒张后张力恢复的时间进程相似，而NO作用后张力的恢复则快得多。在所有情况下，血管张力均可通过氧合血红蛋白（10⁻⁵ M）恢复。结果表明，二亚硝基铁与半胱氨酸的复合物可能在血管中作为内皮源性舒张因子发挥作用。
