苏云金芽孢杆菌磷脂酰肌醇特异性磷脂酶C对实性棘细胞癌的作用
Effect of phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis on solid spinocellular carcinoma.
作者信息
Sarafov D, Trifonov B, Ivanov A, Kamberov E, Zaprjanov Z, Pavlov P, Georgieva E
机构信息
Department of Physiology, Institute of Medicine, Plovdiv, Bulgaria.
出版信息
Toxicon. 1992 Feb;30(2):187-95. doi: 10.1016/0041-0101(92)90471-g.
Phosphatidylinositol-specific phospholipase C (PIPLC) from Bacillus thuringiensis (0.11 units per ml) inhibited growth of IC-Sofia carcinoma cell line in culture by 64%. The growth of transplanted carcinoma in hamsters was also inhibited by 29% at a dose of 4.9 units of PIPLC/kg animal/day. In addition, degeneration processes and a significant fibrosis of the tumour occurred. The functional, clinical, biochemical and haematological parameters studied were consistent with the established antitumour effect in vivo.
来自苏云金芽孢杆菌的磷脂酰肌醇特异性磷脂酶C（PIPLC）（每毫升0.11单位）可使培养中的IC - 索菲亚癌细胞系生长抑制64%。以4.9单位PIPLC/千克动物/天的剂量给药时，仓鼠体内移植癌的生长也受到29%的抑制。此外，肿瘤出现了变性过程和显著的纤维化。所研究的功能、临床、生化和血液学参数与体内已确立的抗肿瘤作用一致。
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