Gayle H D, Gnaore E, Adjorlolo G, Ekpini E, Coulibaly R, Porter A, Braun M M, Zabban M L, Andou J, Timite A
Division of HIV/AIDS, Centers for Disease Control, Atlanta, Georgia 30333.
J Acquir Immune Defic Syndr (1988). 1992;5(5):513-7.
We conducted a study of 1,003 well and hospitalized children, birth to 5 years old, in Abidjan, Côte d'Ivoire, to determine the prevalence of HIV-1 and HIV-2 infection, evaluate risk factors for infection, and describe associated clinical characteristics. The overall seroprevalence was significantly higher for children in the hospital (10.8%) than for those attending the clinic (3.6%). HIV-1 was the predominant virus in both populations, comprising 87% (hospital) and 77% (clinic) of the seroreactive blood specimens. Ninety-two percent of seroreactive children of all ages had a mother who was HIV positive; 77% of seroreactive children greater than or equal to 15 months old had an HIV-infected mother. The remaining seropositive children had a history of receiving blood transfusions. Hospitalized children who were HIV-1 positive or dually seroreactive were more likely to have HIV-related clinical signs and symptoms than HIV-negative children. These findings suggest that HIV infection is an important cause of morbidity for children in Abidjan and that maternal infection is the primary risk factor for both HIV-1 and HIV-2 infection in children. Further evaluation and attention should be given to transmission, clinical characteristics, and the impact of HIV infection in children in West Africa, where both HIV-1 and HIV-2 are present.
我们在科特迪瓦的阿比让对1003名出生至5岁的健康及住院儿童进行了一项研究，以确定HIV-1和HIV-2感染的患病率，评估感染的风险因素，并描述相关的临床特征。医院儿童的总体血清阳性率（10.8%）显著高于门诊儿童（3.6%）。HIV-1是这两个人群中的主要病毒，在血清反应阳性的血液样本中，医院儿童占87%，门诊儿童占77%。所有年龄段血清反应阳性儿童中有92%的母亲为HIV阳性；15个月及以上血清反应阳性儿童中有77%的母亲感染了HIV。其余血清阳性儿童有输血史。与HIV阴性儿童相比，HIV-1阳性或双重血清反应阳性的住院儿童更有可能出现与HIV相关的临床体征和症状。这些发现表明，HIV感染是阿比让儿童发病的一个重要原因，母亲感染是儿童感染HIV-1和HIV-2的主要风险因素。对于同时存在HIV-1和HIV-2的西非地区儿童，应进一步评估并关注HIV感染的传播、临床特征及其影响。
