Nguyen M L, Borochovitz D, Thomas G, McClure T, Ruben F L
Department of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania 15213.
Clin Infect Dis. 1992 Mar;14(3):767-8. doi: 10.1093/clinids/14.3.767.
A 67-year-old woman who had underlying rheumatoid arthritis and diabetes mellitus had an 8-year history of recurrent hemorrhagic cystitis. During her most recent episode of cystitis, a specimen of urine yielded herpes simplex virus type 2 in culture. A biopsy of the bladder mucosa revealed intranuclear inclusions in multinucleated and mononuclear giant cells that were positive for herpes simplex virus type 2 by immunoperoxidase staining. She had no evidence of infection with herpes simplex virus outside her bladder.
一名67岁患有类风湿性关节炎和糖尿病的女性，有复发性出血性膀胱炎病史8年。在她最近一次膀胱炎发作期间，尿液标本培养出2型单纯疱疹病毒。膀胱黏膜活检显示多核和单核巨细胞内有核内包涵体，免疫过氧化物酶染色显示这些包涵体对2型单纯疱疹病毒呈阳性。她膀胱外没有2型单纯疱疹病毒感染的证据。
