Ueno R
Z Orthop Ihre Grenzgeb. 1976 Feb;114(1):108-12.
Report on the action of GAGPS injected intramuscularly on experimental arthrosis of the knee-joint in dogs. In both hind-legs the lateral tibial joint-surface and the lateral meniscus were resected. This produces arthrotic changes similar to human arthrosis within 2 months. Of 27 dogs 13 received i.m. injections into the glutei of GAGPS (25 mg/kg). 14 dogs were not untreated controls. After the 7th postoperative day the injections were given on every third day on 10 occasions, thereafter every fourth day for another 10 occasions. The animals were killed 3 months after the start of the experiment. Loss of cartilage on the lateral condyle proved to be clearly less pronounced in the treated animals than in the controls, macroscopically, radiologically and histolocally. GAGPS, injected, intragluteally, limits loss of cartilage in experimental arthrosis of the knee in dogs.
关于肌内注射GAGPS对犬膝关节实验性关节病作用的报告。在双侧后肢切除胫骨外侧关节面和外侧半月板。这会在2个月内产生类似于人类关节病的关节变化。27只犬中，13只在臀肌内肌内注射GAGPS（25mg/kg）。14只犬为未处理的对照。术后第7天起，每3天注射1次，共10次，此后每4天注射1次，再进行10次。实验开始3个月后处死动物。在大体、放射学和组织学上，治疗组动物外侧髁软骨损失明显比对照组轻。肌内注射GAGPS可限制犬膝关节实验性关节病中的软骨损失。
