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[硫酸多糖对C57黑鼠遗传性固定性关节病的组织病理学研究改良]

[Histopathologic studies modification of genetically fixed arthrosis in C 57 black mice by glycosaminoglycan polysulfate].

作者信息

Elling H

机构信息

Pharmakologischen Laboratorien des Luitpold-Werkes, Chemisch-pharmazeutische Fabrik, München.

出版信息

Arzneimittelforschung. 1987 Aug;37(8):940-3.

PMID:3675689
Abstract

The effect of the chondroprotective substances glycosaminoglycan polysulfate (GAGPS) and chondroitin sulfate upon the genetically fixed osteoarthritis of C 57-black mice has been investigated. The histological preparation showed that at the age of 13 months all mice suffered from more or less severe articular changes resembling an osteoarthritis of the knee. In comparison to the control group, however, the degree of severity and the frequency of the arthrotic changes were significantly lower in the GAGPS groups. Moreover, a dose-dependent effect of GAGPS was found.

摘要

研究了软骨保护物质多硫酸糖胺聚糖（GAGPS）和硫酸软骨素对C57黑小鼠遗传性固定性骨关节炎的影响。组织学制备显示，在13个月大时，所有小鼠都或多或少患有类似于膝关节骨关节炎的严重关节变化。然而，与对照组相比，GAGPS组关节变化的严重程度和频率明显较低。此外，还发现了GAGPS的剂量依赖性效应。

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1
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Arzneimittelforschung. 1987 Aug;37(8):940-3.
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[Chondroprotective and antiarthrotic properties of glycosaminoglycan polysulfate (GAGPS) in gonarthrosis in animal experiments].[硫酸氨基葡聚糖（GAGPS）在动物实验性膝关节炎中的软骨保护和抗关节炎特性]
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[Clinical testing of intra-articularly injected glycosaminoglycan polysulfate in gonarthrosis ( a controlled multicenter double-blind study)].[硫酸氨基聚糖关节腔内注射治疗膝关节炎的临床测试（一项对照多中心双盲研究）]
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