Zee R Y, Lou Y K, Griffiths L R, Morris B J
Department of Physiology, University of Sydney, N.S.W., Australia.
Biochem Biophys Res Commun. 1992 Apr 15;184(1):9-15. doi: 10.1016/0006-291x(92)91150-o.
Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors are effective antihypertensive agents. A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93 normotensive (NT) subjects whose parents had a similar BP status at age greater than or equal to 50. The frequency of the insertion allele was 0.56 in HTs and 0.41 in NTs, and the difference between observed alleles in all subjects in each group was significant (chi 2 = 7.6, P less than 0.01). The data thus provide evidence in favour of an association of HT with a polymorphism at the ACE locus (17q23), so implicating this locus, and possibly a genetic variant of ACE itself, in human essential hypertension.
血管紧张素I转换酶（ACE）负责血管紧张素II的生成和激肽的分解，从而导致血压（BP）升高。此外，ACE抑制剂是有效的抗高血压药物。在一项横断面研究中，对80名高血压（HT）患者和93名血压正常（NT）患者进行了PCR检测，这些患者的父母在年龄大于或等于50岁时血压状况相似，检测了ACE基因第16内含子中的一个287 bp插入/缺失多态性。插入等位基因在HT患者中的频率为0.56，在NT患者中为0.41，每组所有受试者中观察到的等位基因差异具有统计学意义（卡方 = 7.6，P < 0.01）。因此，这些数据为HT与ACE基因座（17q23）多态性之间的关联提供了证据，从而表明该基因座以及可能ACE本身的一个基因变体与人类原发性高血压有关。
