血管紧张素转换酶插入/缺失多态性与沙特人群 2 型糖尿病的关系。
Association between Angiotensin-Converting Enzyme- Insertion/Deletion Polymorphism and Diabetes Mellitus-2 in Saudi Population.
机构信息
Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Jazan University, Saudi Arabia.
Department of Medicine, University Of Cambridge, United Kingdom.
出版信息
Asian Pac J Cancer Prev. 2021 Jan 1;22(1):119-123. doi: 10.31557/APJCP.2021.22.1.119.
OBJECTIVES
The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the development of type 2 diabetes mellitus (T2DM) has been debated vigorously but still remains controversial. Therefore, the current study was designed to determine the possible association between ACE I/D polymorphism and T2DM and hypertension (HTN) in a population of Saudi Arabian participants.
METHODS
A total of 143 individuals were recruited for the study, consisting of 74 controls and 69 patients with T2DM. Genotyping was performed via polymerase chain reaction.
RESULTS
The genotype frequencies for DD, ID and II in controls were 52.7%, 39.2% and 8.1%, whereas in T2D patients it was 52.2%, 40.6% and 7.2% respectively. The DD frequency was highest out of the three genotypes in both the controls and the T2DM patients.
CONCLUSION
There was no significant difference found in the genotype and allele frequencies between cases and controls, suggesting that insertion/deletion polymorphism in the ACE gene may not be associated with an increased susceptibility to type 2 diabetes in our study population.
目的
血管紧张素转换酶（ACE）插入/缺失（I/D）多态性与 2 型糖尿病（T2DM）的发展之间的关联一直存在激烈争论，但仍存在争议。因此，本研究旨在确定 ACE I/D 多态性与沙特阿拉伯人群中 T2DM 和高血压（HTN）之间的可能关联。
方法
共招募了 143 名参与者进行研究，其中 74 名为对照组，69 名为 T2DM 患者。通过聚合酶链反应进行基因分型。
结果
对照组的 DD、ID 和 II 基因型频率分别为 52.7%、39.2%和 8.1%，而 T2D 患者的基因型频率分别为 52.2%、40.6%和 7.2%。在对照组和 T2DM 患者中，三种基因型中 DD 频率最高。
结论
病例组和对照组之间的基因型和等位基因频率没有发现显著差异，提示 ACE 基因插入/缺失多态性与我们研究人群中 2 型糖尿病的易感性增加无关。
Zotero 插件