O'Rourke R A, Henning H, Theroux P, Crawford M H, Ross J
Am J Cardiol. 1976 Apr;37(5):708-15. doi: 10.1016/0002-9149(76)90364-7.
The effects of maintenance oral digoxin therapy on segmental left ventricular wall motion (wall motion videotracking) and left heart size (radiographic left heart dimension) were evaluated in 14 patients with a prior myocardial infarction but without clinical signs or symptoms of congestive heart failure. The left heart dimension decreased in all six patients with cardiomegaly from an average of 55.0 +/- 1.6 (standard deviation) to 52.2 +/- 2.7 mm/m2 body surface area (P less than 0.01) during digoxin therapy. However, there was no significant change in the eight patients with normal heart size. In the resting state, the average extent of shortening in normal segments increased significantly from 3.1 +/- 0.8 to 4.2 +/- 1.2 mm during digoxin therapy. During submaximal handgrip exercise, the extent of shortening averaged 4.0 +/- 1.3 mm and increased further with digoxin therapy to 5.1 +/- 2.1 mm. The effects of digoxin therapy on the maximal velocity of shortening in normal segments at rest and during handgrip exercise were similar. In all 14 patients, there was a decrease in the number of segments with abnormal wall motion at rest or with handgrip exercise during digoxin therapy. With therapy, the number of abnormal sites decreased from 52 to 35 in the resting state and from 84 to 49 during handgrip exercise. Thus, in patients 6 or more months after transmural myocardial infarction, orally administered digoxin decreases cardiomegaly, increases the extent and maximal velocity of shortening in normal left ventricular segments and often reduces the extent of abnormal wall motion at rest or during isometric exercise.
对14例曾患心肌梗死但无充血性心力衰竭临床体征或症状的患者，评估了维持性口服地高辛治疗对左心室节段性室壁运动（室壁运动视频追踪）和左心大小（X线左心径）的影响。在接受地高辛治疗期间，所有6例心脏扩大的患者的左心径从平均55.0±1.6（标准差）降至52.2±2.7mm/体表面积（P<0.01）。然而，8例心脏大小正常的患者无显著变化。在静息状态下，正常节段的平均缩短程度在接受地高辛治疗期间从3.1±0.8mm显著增加至4.2±1.2mm。在次极量握力运动期间，缩短程度平均为4.0±1.3mm，地高辛治疗后进一步增加至5.1±2.1mm。地高辛治疗对静息和握力运动时正常节段最大缩短速度的影响相似。在所有14例患者中，地高辛治疗期间静息或握力运动时室壁运动异常的节段数量减少。治疗后，静息状态下异常部位的数量从52个降至35个，握力运动期间从84个降至49个。因此，在透壁性心肌梗死后6个月或更长时间的患者中，口服地高辛可减小心脏扩大，增加正常左心室节段的缩短程度和最大缩短速度，并常常减少静息或等长运动时室壁运动异常的程度。
