Prestar F J
Neurochirurgische Abteilung, Knappschaftskrankenhaus, Bergmannsheil, Gelsenkirchen-Buer.
Neurochirurgia (Stuttg). 1992 Jan;35(1):1-4. doi: 10.1055/s-2008-1052235.
In a prospective randomized study the effect of low-molecular-weight heparin (one injection of 1500 a PPT-Units/d Mono-Embolex NM) was compared with the effect of unfractionated heparin (5000 IU t.i.d.) in 200 patients undergoing micro-neurosurgical lumbar disc operations. Criteria of evaluation were lethal pulmonary embolisms, clinical signs of pulmonary embolisms, confirmed by radioisotopic lung scans, and major bleeding complications. The present investigation demonstrates, that a single daily subcutaneous injection of Mono-Embolex NM is an effective and well tolerated measure against thrombo-embolic complications, at least equal to the established low dose heparin prophylaxis with 5000 IU t.i.d.
在一项前瞻性随机研究中，对200例接受显微神经外科腰椎间盘手术的患者，比较了低分子量肝素（每日注射1500抗栓酶单位/d单一支链型依诺肝素）与普通肝素（5000IU，每日3次）的效果。评估标准为致死性肺栓塞、经放射性同位素肺扫描证实的肺栓塞临床体征以及严重出血并发症。本研究表明，每日单次皮下注射单一支链型依诺肝素是预防血栓栓塞并发症的一种有效且耐受性良好的措施，至少等同于既定的5000IU每日3次的低剂量肝素预防方案。
