D-青霉胺治疗与快速进展性肾小球肾炎相关。
D-penicillamine therapy associated with rapidly progressive glomerulonephritis.
作者信息
Macarrón P, García Díaz J E, Azofra J A, Martín de Francisco J, Gonzalez E, Fernandez G, Sampedro J
机构信息
Rheumatology Unit, Hospital Virgen de la Salud, Toledo, Spain.
出版信息
Nephrol Dial Transplant. 1992;7(2):161-4. doi: 10.1093/oxfordjournals.ndt.a092089.
A 55-year-old woman with advanced rheumatoid arthritis developed rapidly progressive glomerulonephritis with epithelial crescents and pulmonary hemorrhage following treatment with D-penicillamine. D-penicillamine was then withdrawn and a pulse therapy with methylprednisolone halted the progression of kidney and lung damage. We review the other cases previously reported and discuss pathogenesis and treatment of this rare condition.
一名55岁患有晚期类风湿关节炎的女性在接受青霉胺治疗后，出现了伴有上皮新月体形成的快速进展性肾小球肾炎及肺出血。随后停用青霉胺，甲泼尼龙冲击疗法阻止了肾和肺损害的进展。我们回顾了先前报道的其他病例，并讨论了这种罕见病症的发病机制和治疗方法。
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