Banfi G, Imbasciati E, Guerra L, Mihatsch M J, Ponticelli C
Nephron. 1983;33(1):56-60. doi: 10.1159/000182906.
Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months. Light microscopy study of the kidney showed severe glomerulonephritis with crescent formation in 50% of glomeruli and necrotizing vasculitis. Immunoflurescence revealed IgA and C3 granular deposits diffusely distributed along the capillary walls. The patient was treated with steroid 'pulse', antiplatelet agents and heparin and a partial recovery of renal function was observed after 2 months of anuria. This renal picture is unlike that reported in RA and a causative role for D-penicillamine is suggested.
一名患类风湿关节炎（RA）的女性在接受青霉胺治疗3个月后发生了快速进展性肾小球肾炎。肾脏的光镜检查显示严重的肾小球肾炎，50%的肾小球有新月体形成，并有坏死性血管炎。免疫荧光显示IgA和C3颗粒状沉积物沿毛细血管壁弥漫分布。患者接受了类固醇“冲击”治疗、抗血小板药物和肝素治疗，在无尿2个月后肾功能出现部分恢复。这种肾脏表现与RA中报道的不同，提示青霉胺有致病作用。
