Jones D, Lee L, Liu J L, Kung H J, Tillotson J K
Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
Proc Natl Acad Sci U S A. 1992 May 1;89(9):4042-6. doi: 10.1073/pnas.89.9.4042.
Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.
马立克氏病病毒（MDV）是一种鸡疱疹病毒，在感染后3周内可诱发T淋巴瘤。MDV诱导肿瘤的潜伏期短且具有多克隆性质，这表明该病毒可能编码一种或多种直接作用的癌基因。然而，迄今为止，尚未证实有MDV特异性肿瘤抗原或候选转化基因。在本文中，我们报告了一个MDV基因的鉴定，该基因编码一种与核癌基因亮氨酸拉链类具有同源性的蛋白质。它还包含另一类转录因子特有的富含脯氨酸结构域。这个基因被命名为meq，定位于MDV的长重复序列，是在MDV诱导的T细胞肿瘤中高度表达的少数基因之一。据我们所知，此前尚未报道过与癌基因fos/jun家族密切相关的疱疹病毒基因。
