CI-960（PD127391或AM-1091）、司帕沙星、WIN 57273及异帕米星对鸟分枝杆菌-胞内分枝杆菌复合体、龟分枝杆菌和偶然分枝杆菌临床分离株的活性。
CI-960 (PD127391 or AM-1091), sparfloxacin, WIN 57273, and isepamicin activity against clinical isolates of Mycobacterium avium-intracellularae complex, M. chelonae, and M. fortuitum.
作者信息
Barrett M S, Jones R N, Erwin M E, Koontz F P
机构信息
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242.
出版信息
Diagn Microbiol Infect Dis. 1992 Feb;15(2):169-71. doi: 10.1016/0732-8893(92)90044-t.
A 7H9 broth microdilution method against CI-960, sparfloxacin, WIN57273, ciprofloxacin, norfloxacin, isepamicin, amikacin, kanamycin, ethambutol, isoniazid, and rifampin was used to test 35 Mycobacterium avium-intracellulare complex (MAI) and five M. chelonae-fortuitum strains. The majority of MAI isolates were inhibited by all tested compounds, with sparfloxacin (MIC90, 0.5 micrograms/ml) being the most active among the fluoroquinolones; isepamicin (MIC90, 4 micrograms/ml), the most potent aminoglycoside; and isoniazid, rifampin, and ethambutol also demonstrating some degree of activity. Mycobacterium chelonae strains were resistant to all drugs except ciprofloxacin (MIC50, 1 microgram/ml). Mycobacterium fortuitum isolates were generally susceptible, especially to the newer fluoroquinolones.
采用7H9肉汤微量稀释法检测35株鸟分枝杆菌-胞内分枝杆菌复合体（MAI）和5株龟分枝杆菌-偶然分枝杆菌，检测药物包括CI-960、司帕沙星、WIN57273、环丙沙星、诺氟沙星、异帕米星、阿米卡星、卡那霉素、乙胺丁醇、异烟肼和利福平。大多数MAI分离株被所有检测化合物抑制，司帕沙星（MIC90，0.5微克/毫升）是氟喹诺酮类中活性最强的；异帕米星（MIC90，4微克/毫升）是最有效的氨基糖苷类；异烟肼、利福平和乙胺丁醇也表现出一定程度的活性。龟分枝杆菌菌株对除环丙沙星（MIC50，1微克/毫升）外的所有药物耐药。偶然分枝杆菌分离株通常敏感，尤其是对新型氟喹诺酮类药物。
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