Aukrust P, Farstad I N, Frøland S S, Holter E
Medical Dept A, University of Oslo, National Hospital, Norway.
Eur Respir J. 1992 Mar;5(3):362-4.
We report a case of fatal pulmonary disease in a patient infected with human immunodeficiency virus (HIV), where cytomegalovirus (CMV) was the only causative agent identified in the lungs at autopsy. The most prominent histopathological features were numerous interalveolar cells containing CMV inclusion bodies combined with scanty signs of inflammation. We propose that the lung damage caused by CMV in acquired immune deficiency syndrome (AIDS) patients is a direct consequence of cytopathogenic effects of the virus related to the extent of active virus replication.
我们报告了一例感染人类免疫缺陷病毒（HIV）患者的致命性肺部疾病，尸检时在肺部发现巨细胞病毒（CMV）是唯一确定的病原体。最显著的组织病理学特征是大量含有CMV包涵体的肺泡间细胞，同时炎症迹象稀少。我们认为，获得性免疫缺陷综合征（AIDS）患者中由CMV引起的肺损伤是病毒细胞致病作用与活跃病毒复制程度相关的直接后果。
