Klatt E C, Shibata D
Department of Laboratories and Pathology, Los Angeles County-University of Southern California Medical Center 90033.
Arch Pathol Lab Med. 1988 May;112(5):540-4.
The clinical and autopsy findings of cytomegalovirus (CMV) infection in patients with the acquired immunodeficiency syndrome (AIDS) are reviewed. Of 164 patients, 81 had evidence of CMV infection at autopsy, but organ failure leading to patient demise from CMV occurred in only 17. Demographic differences between patients with AIDS with and without CMV were minimal. Cytomegalovirus was never the sole diagnostic criterion for AIDS in any patient but was always accompanied by at least one other opportunistic infection or neoplasm. The total clinical course did not significantly differ between the two groups, but the length of final hospitalization of patients with CMV was much longer. Therapy for CMV prolonged the clinical course in some cases but did not eliminate the infection or prevent death from CMV. At autopsy the most common sites of involvement were adrenal (75%), pulmonary (58%), gastrointestinal (30%), central nervous system (20%), and ocular (10%). Most patients (62%) had multiple sites of involvement. Gross pathologic findings were frequent but often subtle. Microscopic changes accompanying CMV inclusions were variable and usually limited in extent.
对获得性免疫缺陷综合征（AIDS）患者巨细胞病毒（CMV）感染的临床及尸检结果进行了回顾。在164例患者中，81例在尸检时有CMV感染证据，但仅17例因CMV导致器官衰竭而死亡。伴有和不伴有CMV的AIDS患者在人口统计学上差异极小。在任何患者中，CMV从未作为AIDS的唯一诊断标准，而是总是伴有至少一种其他机会性感染或肿瘤。两组患者的总体临床病程无显著差异，但CMV感染患者的最终住院时间要长得多。CMV治疗在某些情况下延长了临床病程，但并未消除感染或预防因CMV导致的死亡。尸检时，最常受累的部位是肾上腺（75%）、肺（58%）、胃肠道（30%）、中枢神经系统（20%）和眼部（10%）。大多数患者（62%）有多个受累部位。大体病理表现常见但往往不明显。伴有CMV包涵体的微观变化各不相同，且通常范围有限。
