Chow L C, Takagi S, Shih S
American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, Maryland 20899.
J Dent Res. 1992 Mar;71(3):443-7. doi: 10.1177/00220345920710030401.
A previous study showed that a two-solution fluoride (F) rinse deposited significantly more loosely-bound F on the tooth surface than did a sodium fluoride (NaF) rinse with the same F concentration (12 mmol/L). In the present study, this experimental rinse was evaluated for its ability to cause remineralization of enamel lesions in an in vitro pH-cycling model. Caries-like lesions were formed in the enamel of extracted human molars by means of a pH 4 demineralizing solution. Fifty-one approximately 120-microns-thick sections containing lesions were randomly divided into (1) control, (2) NaF rinse, and (3) two-solution F rinse groups. With the cut surfaces protected, the control samples were immersed in a pH 7 remineralizing solution for 12 days, and twice daily the sections were also exposed to a pH 4 demineralizing solution for 30 min. Samples in the NaF group received an additional one-minute rinse with a NaF (12 mmol/L) solution twice daily. Samples in the two-solution rinse group received the rinse treatment with a 12 mmol/L F solution prepared by combination of a Na2SiF6 and phosphate-containing solution with a calcium solution just before use. The mineral contents of the lesions were assessed by quantitative microradiography. The results showed that (1) no significant de- or remineralization was detected in the controls; (2) a 46% decrease in mineral loss (delta Z) of the lesion was produced by the NaF rinses; and (3) a 94% decrease in delta Z and a 20-microns-thick, mineral-dense surface-coating were produced by the two-solution F rinse treatment.
先前的一项研究表明，与相同氟浓度（12 mmol/L）的氟化钠（NaF）漱口水相比，双液氟（F）漱口水在牙齿表面沉积的松散结合氟要多得多。在本研究中，在体外pH循环模型中评估了这种实验性漱口水导致釉质病变再矿化的能力。通过pH 4脱矿溶液在拔除的人类磨牙釉质中形成龋样病变。将51个包含病变的约120微米厚切片随机分为（1）对照组、（2）NaF漱口水组和（3）双液F漱口水组。在保护切面的情况下，将对照样品浸入pH 7再矿化溶液中12天，并且每天两次将切片暴露于pH 4脱矿溶液中30分钟。NaF组的样品每天额外用NaF（12 mmol/L）溶液冲洗一分钟两次。双液冲洗组的样品在使用前用由六氟硅酸钠和含磷酸盐溶液与钙溶液混合制备的12 mmol/L F溶液进行冲洗处理。通过定量显微放射照相术评估病变的矿物质含量。结果表明：（1）在对照组中未检测到明显的脱矿或再矿化；（2）NaF漱口水使病变的矿物质损失（ΔZ）减少了46%；（3）双液F冲洗处理使ΔZ减少了94%，并产生了20微米厚的矿物质致密表面涂层。
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