Dickens Sabine H, Flaim Glenn M
American Dental Association Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, MD 20899-8546, USA.
Dent Mater. 2008 Sep;24(9):1273-80. doi: 10.1016/j.dental.2008.02.004. Epub 2008 Mar 24.
To test whether fluoride in a resin-based Ca-PO4 ion releasing cement or coating with an acidic bonding agent for improved adhesion compromised the cement remineralization potential.
Cements were formulated without fluoride (Cement A) or with fluoride (Cement B). The treatment groups were A=Cement A; A2=Cement A+bonding agent; B=Cement B; B2=Cement B+bonding agent. The calcium, phosphate, and fluoride ion release in saliva-like solution (SLS) was determined from hardened cement disks without or with a coating of bonding agent. For the remineralization, two cavities were prepared in dentin of extracted human molars and demineralized. One cavity received composite resin (control); the other received treatment A, A2, B or B2. After 6 week incubation in SLS, 180 microm cross-sections were cut. The percentage remineralization was determined by transverse microradiography comparing the dentin mineral density under the cement to that under the control.
The percentage of remineralization (mean+/-S.D.) was A (39+/-14)=B (37+/-18), A2 (23+/-13), B2 (14+/-7). Two-way analysis of variance (ANOVA) and Holm-Sidak test showed a significant effect from the presence of bonding agent (p<0.05), but not from fluoride (p>0.05). The ion solution concentrations of all groups showed undersaturation with respect to dicalcium phosphate dihydrate and calcium fluoride and supersaturation for fluorapatite and hydroxyapatite suggesting a positive remineralization potential.
Compared to the control all treatments resulted in mineral increase. The remineralization was negatively affected by the presence of the bonding agent.
测试基于树脂的钙 - 磷离子释放水泥中的氟化物或用酸性粘结剂涂层以改善粘结性是否会损害水泥的再矿化潜力。
配制不含氟化物的水泥（水泥A）或含氟化物的水泥（水泥B）。治疗组分别为：A = 水泥A；A2 = 水泥A + 粘结剂；B = 水泥B；B2 = 水泥B + 粘结剂。在有无粘结剂涂层的硬化水泥盘上测定其在唾液样溶液（SLS）中的钙、磷和氟离子释放量。对于再矿化，在拔除的人磨牙牙本质中制备两个洞并使其脱矿。一个洞填充复合树脂（对照）；另一个洞接受治疗A、A2、B或B2。在SLS中孵育6周后，切割180微米的横截面。通过横向显微放射照相术比较水泥下牙本质的矿物质密度与对照下的牙本质矿物质密度，确定再矿化百分比。
再矿化百分比（平均值±标准差）为：A（39±14）= B（37±18），A2（23±13），B2（14±7）。双向方差分析（ANOVA）和Holm - Sidak检验表明，粘结剂的存在有显著影响（p < 0.05），但氟化物无显著影响（p > 0.05）。所有组的离子溶液浓度相对于二水磷酸二钙和氟化钙显示不饱和，而对于氟磷灰石和羟基磷灰石显示过饱和，表明有积极的再矿化潜力。
与对照相比，所有治疗均导致矿物质增加。粘结剂的存在对再矿化有负面影响。
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