一种在内质网中早期参与多肽转运的蛋白质。
A protein of the endoplasmic reticulum involved early in polypeptide translocation.
作者信息
Görlich D, Hartmann E, Prehn S, Rapoport T A
机构信息
Max-Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.
出版信息
Nature. 1992 May 7;357(6373):47-52. doi: 10.1038/357047a0.
DOI:10.1038/357047a0
PMID:1315422
Abstract
To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.
摘要
为了鉴定参与分泌蛋白转运的哺乳动物内质网成分，将交联和重组方法结合起来。发现了一种多次跨膜的丰富膜糖蛋白，它在转运早期靠近新生肽链。在重组蛋白脂质体中，这种蛋白对分泌蛋白的转运具有刺激作用或必不可少。
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