γ-亚麻酸对骨肉瘤细胞有丝分裂和核形态的影响。
Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells.
作者信息
de Kock M, Seegers J C, Els H J
机构信息
Department of Physiology, University of South Africa, Pretoria.
出版信息
S Afr Med J. 1992 May 2;81(9):467-72.
PMID:1315459
Abstract
In this study it is shown that gamma-linolenic acid (GLA) at concentrations of 10, 20 and 50 micrograms/ml has a dose-responsive inhibitory effect on mitosis in osteogenic sarcoma cells after exposure for 24, 48 and 72 hours, respectively. GLA also has marked effects on the morphology of the nucleus and nucleolus of these cells. Decreased silver staining of nuclear phosphoproteins was also evident in GLA-supplemented cells.
摘要
本研究表明，γ-亚麻酸（GLA）浓度分别为10、20和50微克/毫升时，在分别暴露24、48和72小时后，对骨肉瘤细胞的有丝分裂具有剂量依赖性抑制作用。GLA对这些细胞的细胞核和核仁形态也有显著影响。在添加GLA的细胞中，核磷蛋白的银染色减少也很明显。
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