[慢性冠状动脉供血不足时肌球蛋白的结构和功能变化]
[Structural and functional changes in myosin in chronic coronary insufficiency].
作者信息
Davydova S M, Kalamkarova M B, Kolesova O E, Podlubnaia Z A, Chechulin Iu S
出版信息
Biofizika. 1976 Mar-Apr;21(2):295-9.
PMID:131586
Abstract
A study of myosin extracted from dog's cardiac muscle at different stages of chronic heart failure (from 1 week to 1 year) was carried out. A decrease of UV-luminescence intensity, flow birefringence and ATPase activity (to 70%) was observed. The electron microscopic investigation of myosin and LMM structure shows the loss of ability to form typical paracrystals by LMM, the electron microscopic appearance of the whole myosin being unchanged.
摘要
对从慢性心力衰竭不同阶段（从1周到1年）的犬心肌中提取的肌球蛋白进行了一项研究。观察到紫外线发光强度、流动双折射和ATP酶活性降低（降至70%）。对肌球蛋白和轻酶解肌球蛋白（LMM）结构的电子显微镜研究表明，LMM形成典型副晶体的能力丧失，而整个肌球蛋白的电子显微镜外观未发生变化。
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