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地西泮可拮抗苯环己哌啶(PCP)受体激动剂对多巴胺代谢产生的影响。

Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists.

作者信息

Bowers M B, Morton J B

机构信息

Department of Psychiatry, Yale University, New Haven, CT.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1992 Mar;16(2):211-5. doi: 10.1016/0278-5846(92)90072-m.

DOI:10.1016/0278-5846(92)90072-m
PMID:1315975
Abstract
  1. Male rats were injected with either saline, diazepam, MK-801, or diazepam plus MK-801. 2. In previous work with phencyclidine (PCP), diazepam significantly reduced the increase in homovanillic acid (HVA) in olfactory tubercle and prefrontal cortex. 3. Diazepam also lowered the HVA increase following MK-801 in caudate, olfactory tubercle, and prefrontal cortex. 4. Benzodiazepine receptors may modify dopaminergic function at PCP receptors that affect dopamine neurotransmission.
摘要
  1. 给雄性大鼠注射生理盐水、地西泮、MK-801或地西泮加MK-801。2. 在先前使用苯环己哌啶(PCP)的研究中,地西泮显著降低了嗅结节和前额叶皮质中高香草酸(HVA)的增加。3. 地西泮还降低了尾状核、嗅结节和前额叶皮质中MK-801注射后HVA的增加。4. 苯二氮䓬受体可能在影响多巴胺神经传递的PCP受体处调节多巴胺能功能。

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Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists.地西泮可拮抗苯环己哌啶(PCP)受体激动剂对多巴胺代谢产生的影响。
Prog Neuropsychopharmacol Biol Psychiatry. 1992 Mar;16(2):211-5. doi: 10.1016/0278-5846(92)90072-m.
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Antagonism of ceruletide, a cholecystokinin analog, to the neurochemical effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine and MK-801, on regional dopaminergic neurons in the rat brain.蛙皮素(一种胆囊收缩素类似物)对非竞争性N-甲基-D-天冬氨酸(NMDA)受体拮抗剂苯环利定和MK-801对大鼠脑内局部多巴胺能神经元的神经化学作用的拮抗作用。
Neuropeptides. 1992 Mar;21(3):167-73. doi: 10.1016/0143-4179(92)90041-t.
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The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents.甘氨酸/N-甲基-D-天冬氨酸受体拮抗剂R-(+)-HA-966可阻断苯环利定和地佐环平(MK-801)在啮齿动物中诱导的中脑边缘多巴胺能系统的激活。
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Neuropharmacology. 1990 Mar;29(3):225-30. doi: 10.1016/0028-3908(90)90005-c.
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Eur J Pharmacol. 1998 Jan 2;341(1):45-56. doi: 10.1016/s0014-2999(97)01435-0.
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Homovanillic acid in rat caudate and prefrontal cortex following phencyclidine and amphetamine.苯环己哌啶和苯丙胺作用后大鼠尾状核和前额叶皮质中的高香草酸
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Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.苯环利定及相关化合物通过一种独立于苯环利定受体、σ结合位点或多巴胺摄取位点的机制,诱发大鼠中脑细胞培养物释放[3H]多巴胺。
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Neurotoxicol Teratol. 1994 Jul-Aug;16(4):335-42. doi: 10.1016/0892-0362(94)90021-3.

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