地西泮可拮抗苯环己哌啶（PCP）受体激动剂对多巴胺代谢产生的影响。
Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists.
作者信息
Bowers M B, Morton J B
机构信息
Department of Psychiatry, Yale University, New Haven, CT.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1992 Mar;16(2):211-5. doi: 10.1016/0278-5846(92)90072-m.
PMID:1315975
Abstract
- Male rats were injected with either saline, diazepam, MK-801, or diazepam plus MK-801. 2. In previous work with phencyclidine (PCP), diazepam significantly reduced the increase in homovanillic acid (HVA) in olfactory tubercle and prefrontal cortex. 3. Diazepam also lowered the HVA increase following MK-801 in caudate, olfactory tubercle, and prefrontal cortex. 4. Benzodiazepine receptors may modify dopaminergic function at PCP receptors that affect dopamine neurotransmission.
摘要
- 给雄性大鼠注射生理盐水、地西泮、MK-801或地西泮加MK-801。2. 在先前使用苯环己哌啶（PCP）的研究中，地西泮显著降低了嗅结节和前额叶皮质中高香草酸（HVA）的增加。3. 地西泮还降低了尾状核、嗅结节和前额叶皮质中MK-801注射后HVA的增加。4. 苯二氮䓬受体可能在影响多巴胺神经传递的PCP受体处调节多巴胺能功能。
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