四氢大麻酚、苯环己哌啶和MK-801作用后区域脑内儿茶酚胺及其代谢产物
Regional brain catecholamines and metabolites following THC, PCP and MK-801.
作者信息
Bowers M B, Morton J B
机构信息
Yale University Department of Psychiatry, New Haven, CT.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1994 Sep;18(5):961-4. doi: 10.1016/0278-5846(94)90111-2.
PMID:7972865
Abstract
- THC, PCP, and MK-801 increased DOPAC in rat olfactory tubercle and prefrontal cortex without affecting DA levels, suggesting increased DA release. 2. Effects on NE and MHPG were not evident. 3. These two classes of drugs can effect dopaminergic systems independently of noradrenergic systems.
摘要
- 四氢大麻酚、苯环己哌啶和MK - 801可使大鼠嗅结节和前额叶皮质中的3,4 - 二羟基苯乙酸增加，而不影响多巴胺水平，提示多巴胺释放增加。2. 对去甲肾上腺素和3 - 甲氧基 - 4 - 羟基苯乙二醇的影响不明显。3. 这两类药物可独立于去甲肾上腺素能系统影响多巴胺能系统。
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