Sletnes K E, Wisløff F, Moe N, Dale P O
Hematological Research Laboratory, Ullevål University Hospital, Oslo, Norway.
Acta Obstet Gynecol Scand. 1992 Feb;71(2):112-7. doi: 10.3109/00016349209007966.
The significance of antiphospholipid antibodies in pre-eclamptic women has not been thoroughly elucidated. The purpose of this study was to determine the proportion of pre-eclamptic women who were antiphospholipid antibody positive, and to elucidate the significance of these antibodies regarding growth retardation and neonatal outcome. Positive levels of anticephalin antibodies, which are antiphospholipid antibodies, were detected in 7 (19%) out of 37 pre-eclamptic women, as compared with none of 40 in a control group of normotensive women at similar stage of pregnancy (p = 0.004). The birthweight percentiles of the neonates of anticephalin antibody positive women were significantly lower than those of the neonates of anticephalin antibody negative women (p = 0.018). Four of 7 infants of anticephalin antibody positive women were growth retarded (less than 2.5th percentile). This was a significantly larger proportion than that for anticephalin antibody negative women (3/30) (p = 0.004). The 95% confidence interval for the difference between the two proportions was 0.10 to 0.85. Two of the 7 neonates of anticephalin antibody positive women died during the neonatal period, compared with none of the 30 neonates of anticephalin antibody negative women (p = 0.003). Thus, our study suggests that positive levels of anticephalin antibodies in pre-eclamptic women increase the risk for growth retardation and neonatal death.
抗磷脂抗体在子痫前期女性中的意义尚未得到充分阐明。本研究的目的是确定子痫前期女性中抗磷脂抗体阳性的比例，并阐明这些抗体在胎儿生长受限和新生儿结局方面的意义。在37例子痫前期女性中，有7例（19%）检测到抗磷脂抗体之一的抗心磷脂抗体呈阳性，而在妊娠相似阶段的40例血压正常的女性对照组中，无一例呈阳性（p = 0.004）。抗心磷脂抗体阳性女性所生新生儿的出生体重百分位数显著低于抗心磷脂抗体阴性女性所生新生儿（p = 0.018）。抗心磷脂抗体阳性女性的7例婴儿中有4例生长受限（低于第2.5百分位数）。这一比例显著高于抗心磷脂抗体阴性女性（3/30）（p = 0.004）。两组比例差异的95%置信区间为0.10至0.85。抗心磷脂抗体阳性女性的7例新生儿中有2例在新生儿期死亡，而抗心磷脂抗体阴性女性的30例新生儿中无一例死亡（p = 0.003）。因此，我们的研究表明，子痫前期女性抗心磷脂抗体阳性会增加胎儿生长受限和新生儿死亡的风险。
