el-Roeiy A, Myers S A, Gleicher N
Department of Obstetrics and Gynecology, Mount Sinai Hospital Medical Center, Chicago, Illinois.
Am J Obstet Gynecol. 1991 May;164(5 Pt 1):1253-61. doi: 10.1016/0002-9378(91)90695-n.
Abnormal levels of autoantibodies have recently been demonstrated in patients with hypertensive disorders of pregnancy and patients whose fetuses have intrauterine growth retardation. We determined total immunoglobulin levels (immunoglobulin G, immunoglobulin M, and immunoglobulin A) and a broad panel of autoantibodies (six antiphospholipid, four antihistone, and four antipolynucleotide antibodies) in 50 normotensive pregnant females, 19 patients with preeclampsia, and 18 patients with chronic hypertension to examine the relationship to intrauterine growth retardation. Mothers who were delivered of infants with intrauterine growth retardation demonstrated significantly more autoantibody abnormalities in the two hypertensive groups and in the normotensive control group as compared with patients delivered of appropriately grown infants. The most frequently observed autoantibody abnormalities were antiphospholipid antibodies and the most frequently observed among those were immunoglobulin G isotypes. Total immunoglobulin levels in both hypertensive and normotensive groups were identical. These results suggest a close association between the degree of B-cell activation and both severity of hypertensive diseases and development of intrauterine growth retardation in their offspring.
近期研究表明，妊娠高血压疾病患者以及胎儿出现宫内生长受限的患者体内存在异常水平的自身抗体。我们测定了50名血压正常的孕妇、19名先兆子痫患者和18名慢性高血压患者的总免疫球蛋白水平（免疫球蛋白G、免疫球蛋白M和免疫球蛋白A）以及一系列广泛的自身抗体（六种抗磷脂抗体、四种抗组蛋白抗体和四种抗多核苷酸抗体），以研究其与宫内生长受限的关系。与分娩出发育正常婴儿的患者相比，分娩出宫内生长受限婴儿的母亲在两个高血压组和血压正常的对照组中表现出明显更多的自身抗体异常。最常观察到的自身抗体异常是抗磷脂抗体，其中最常见的是免疫球蛋白G亚型。高血压组和血压正常组的总免疫球蛋白水平相同。这些结果表明，B细胞激活程度与高血压疾病的严重程度及其后代宫内生长受限的发生密切相关。
