Sishta S K, Templer D I
Can Med Assoc J. 1976 May 8;114(9):798-9.
Sixteen patients with Huntington's chorea were treated for periods as long as 8 months with levodopa. The condition of none of the patients improved; in fact, there appeared to be an exacerbation of chorea and dementia in addition to undesirable behavioural changes. Therefore, future use of levodopa in these patients is not warranted. The postulated association of low homovanillic acid values in cerebrospinal fluid and favourable response to levodopa therapy was not borne out.
16名患有亨廷顿舞蹈症的患者接受了长达8个月的左旋多巴治疗。没有一名患者的病情得到改善；事实上，除了出现不良行为变化外，舞蹈症和痴呆症似乎还加重了。因此，不建议未来在这些患者中使用左旋多巴。脑脊液中高香草酸值低与左旋多巴治疗反应良好之间的假定关联并未得到证实。
