Roccatagliata G, Pizio N, Farinini D, Firpo M P, Bartolini A, Bacigalupo F, Albano C
Rev Neurol (Paris). 1983;139(10):589-92.
Serotoninergic function has been evaluated in 15 H.C. patients. Therapeutic results obtained with an inhibitor of 5 HT reuptake (Fenfluramine) were evaluated in comparison to the effects of L-5HTP, CSF-5HIAA measurements were performed is each case before and after treatment. The pathological role of 5HT impairment in H. C. can not be excluded by the behavioral effects and CSF-5HIAA modifications that were observed.
对15名肝豆状核变性（H.C.）患者的血清素能功能进行了评估。将5-羟色胺（5-HT）再摄取抑制剂（芬氟拉明）的治疗效果与L-5-羟色氨酸（L-5HTP）的效果进行了比较评估，在每个病例治疗前后均进行了脑脊液5-羟吲哚乙酸（CSF-5HIAA）测量。观察到的行为效应和脑脊液5-羟吲哚乙酸的变化不能排除5-羟色胺功能损害在肝豆状核变性中的病理作用。
