Hill P, Wynder E L, Helman P, Hickman R, Rona G
Cancer Res. 1976 Jun;36(6):1883-5.
Evidence suggests that the reliability of urinary androgens or estrogens as prognostic discriminants for breast cancer may vary with different populations and may bear little relation to changes in plasma hormone levels. In this study the plasma estradiol level was significantly lower in Bantu, but did not in Caucasian, women with breast cancer, while the proportion of plasma androstenedione to dehydroepiandrosterone increased in Bantu patients. These changes in the plasma hormone profile in Bantu patients, a low-risk population for breast cancer, imply a change in ovarian and/or adrenal activity. Lack of similar hormone changes in Caucasian patients may be due to the initial differences in the hormone profile between the healthy Caucasian and Bantu women and to the different environmental factors that promote the breast disease in Western women.
有证据表明，尿雄激素或雌激素作为乳腺癌预后判别指标的可靠性可能因人群不同而异，且可能与血浆激素水平的变化关系不大。在本研究中，患乳腺癌的班图族女性血浆雌二醇水平显著低于白种族女性，而班图族患者血浆雄烯二酮与脱氢表雄酮的比例升高。乳腺癌低风险人群班图族患者血浆激素谱的这些变化意味着卵巢和/或肾上腺活动的改变。白种族患者缺乏类似的激素变化可能是由于健康白种族女性和班图族女性之间激素谱的初始差异，以及促进西方女性患乳腺疾病的不同环境因素。
